As an avowed Arkham Horror junkie, the recent news from Fantasy Flight interests me greatly. They announced a new Lovecraft horror title, Mansions of Madness: http://www.fantasyflightgames.com/edge_minisite.asp?eidm=136
From the marketing speak, it sounds like a mix of Arkham Horror, with abstract board movement and a developing narrative, Descent / Doom, with the “us versus the keeper” dynamic and Betrayal at House on the Hill with the ever-changing maps.
Sounds like fun! Now if only there were a projected release date.